Postoperative Cognitive Dysfunction
Conditions
Interventions
Magnesium sulfate group:Intraoperative infusion of magnesium sulfate
Control group:Intraoperative infusion of saline
Sponsors
the Affiliated Hospital of Jiangnan University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Classified as ASA II to III according to the American Society of Anesthesiologists (ASA) physical status classification 2.Preoperative Montreal Cognitive Assessment (MoCA) score = 26 and Mini-Mental State Examination (MMSE) score > 23." 3.Planned to undergo laparoscopic colon cancer surgery with general anesthesia and endotracheal intubation 4.The expected duration of the surgery is at least 2 hours.
Exclusion criteria
Exclusion criteria: 1. Significant neurological and psychiatric disorders 2. Renal impairment (serum creatinine > 177 µmol/L) or active liver disease. 3. Recent use of sedative-hypnotics, analgesics, and antidepressants 4. History of drug and alcohol abuse 5. Severe visual and hearing impairments affecting communication 6. Preoperative infection, recent use of corticosteroids or other immunosuppressants 7. Contraindications for the use of magnesium sulfate 8. Transfusion of more than 3 units of red blood cells during the perioperative period 9. Unable to understand or cooperate in completing the assessment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Post-Operative Cognitive Dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Consumption of anesthetic agents;Extubation time;Postoperative pain;Postoperative Nausea and Vomiting;Dynamic heart rate changes;Dynamic blood pressure changes.; | — |
Countries
China
Contacts
Public ContactGuangling Li
Affiliated Hospital of Jiangnan University
Outcome results
None listed