Alzheimer disease
Conditions
Interventions
Experimental group (Surgical group):Perform bilateral deep neck lymphatic-vein anastomosis
Sponsors
Zhengzhou Central Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Clinical diagnosis of AD related MCI and mild to moderate Alzheimer's disease patients 2.Age range is 50-90 years old 3.Patients can cooperate to complete medical examinations such as neuropsychological assessments, physical examinations, and head MRI 4.Voluntarily participate in this study, provide biological samples, and sign an informed consent form
Exclusion criteria
Exclusion criteria: 1.Existence of congenital intellectual disabilities and severe neurological and psychiatric disorders 2.Malignant tumors and organ failure that have been clearly diagnosed 3.Severe visual or hearing impairment may not be compatible with neuropsychological assessors 4.Individuals with poor cardiovascular and pulmonary function who cannot tolerate anesthesia 5.Inadequate exposure of surgical site 6.Family members who have not signed informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CDR-SB; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuroimaging examination;Detection of cerebrospinal fluid or blood markers; | — |
Countries
China
Contacts
Public ContactZhao Meiying
Zhengzhou Central Hospital
Outcome results
None listed