female reproductive system disease
Conditions
Interventions
Gold Standard:HPV testing, cytology, colposcopy, histopathology
Index test:Detection of SOX1 and PAX1 gene methylation in human cervical exfoliated cells
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Adult female >=18 years old (2) Patients with abnormal HPV/TCT results and suspected type III conversion areas were observed; (3) Cervical type III transformation area was observed under colposcopy and met the LLETZ indication; (4) no history of cervical cancer surgery; (5) Patients voluntarily join the project study, sign the informed consent, and be able to comply with the examination and research procedures. (6) No sexual life, vaginal medication and irrigation within 3 days of sampling;
Exclusion criteria
Exclusion criteria: (1) Patients with insufficient cervical cell sampling or who cannot complete the sampling; (2) Patients who quit midway or cannot complete the examination process; (3) Patients with incomplete relevant test results and diagnostic information; (4) Patients who have completed colposcopy or biopsy examination in other hospitals; (5) Those who were not considered suitable for inclusion by the researchers. (6) Women in the menstrual period or pregnancy; (7) People who undergo any vaginal examination or use other similar products within two days of sampling;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sensitivity;clinical specificity;positive predictive value;negative predictive value; | — |
Countries
China
Contacts
Public ContactZhang Dai
Peking University First Hospital
Outcome results
None listed