Male Obesity-associated Secondary Hypogonadism
Conditions
Interventions
MOSH with Semaglutide therapy:Semaglutide therapy
MOSH with testosterone treatment:testosterone injection
obesity group:Life style intervention
control:none
Sponsors
The Seventh Affiliated Hospital Sun Yat-sen University
Eligibility
Sex/Gender
Male
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.control: Obesity(18.5 kg/m^2 = 28kg/m^2); Male, age 20 to 30 years old; Without clinical symptoms of low androgen; Without low blood total testosterone compared to normal. 3.MOSH group: Obesity (BMI>=28kg/m^2); Male, age 20 to 30 years old; Clinical symptoms of low androgen; Low blood total testosterone compared to normal; Other diseases lead to low androgen excluded.
Exclusion criteria
Exclusion criteria: (1) Primary testicular dysfunction, (2) Hypogonadism caused by pituitary diseases, (3) Hypogonadism caused by thyroid and adrenal diseases, (4) Taking medications that may cause weight changes within 3 months, (5) Chronic liver and kidney diseases or tumors, such as patients with a history of medullary thyroid cancer or family history, and patients with type 2 multiple endocrine adenoma syndrome, (6) Combined with contraindications to GLP-1 RA drugs such as hyperlipidemia and pancreatitis, (7) Combined with abnormal glucose and lipid metabolism, (8) Patients with chronic malabsorption syndrome and cholestasis, (9) Organ transplant recipients and patients taking environmentally friendly antibiotics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sperm motility;sperm count; | — |
Secondary
| Measure | Time frame |
|---|---|
| BMI;sex hormone;IIEF-5; | — |
Countries
China
Contacts
Public ContactFangping Li
The Seventh Affiliated Hospital Sun Yat-sen University
Outcome results
None listed