Postoperative pulmonary complications
Conditions
Interventions
Low FiO2 group:Received the lowest possible FiO2 that maintained intra-operative SpO2 of at least 94%, down to a minimum of 21%.
Low FiO2 and recruitment maneuvers group:Received the lowest possible FiO2 that maintained intra-operative SpO2 of at least 94% (down to a minimum of 21%) and standard recruitment maneuvers
High FiO2 group:Received 80% FiO2
80% FiO2 and recruitment maneuvers group:Received 80% FiO2 and standard recruitment maneuvers
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age =18 years; 2. ASA classification I-III; 3. With intermediate-high risk of pulmonary complications measured by the Assess Respiratory Risk in Surgical Patients in Catalonia (ARISCAT) risk score =26; 4. Scheduled for elective abdominal surgery under general anaesthesia and expected to be extubated; 5. Written inform consent.
Exclusion criteria
Exclusion criteria: 1. Had pneumothorax, subcutaneous emphysema, mediastinal emphysema, or bullae of lung 2. Persistent hemodynamic instability 3. Preoperative SpO2 = 94 in room air or partial pressure of carbon dioxide in artery > 45 mmHg; 4. With the history of severe chronic obstructive pulmonary disease (COPD, defined as GOLD grade of III - IV), pulmonary fibrosis, uncontrolled asthma, or FEV1/FVC = 70% 5. Had neuromuscular diseases (thymoma, myasthenia, myopathy, muscular dystrophy, etc.) 6. With the history of lung surgery 7. Pregnancy or lactation 8. Enrollment in another clincal study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of pulmonary complications within the postoperative 7 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of hypoxemia within the 1 hour after extubation;Severity grade of pulmonary complications within the postoperative 7 days;The incidence of pulmonary complications within the postoperative 30 days;The incidence of re-intubation within the postoperative 30 days;The incidence of unplanned ICU admission within the postoperative 30 days;The all-cause mortality within the postoperative 30 days; | — |
Countries
China
Contacts
Public ContactHai Yu
West China Hospital of Sichuan University
Outcome results
None listed