Postoperative Subsyndromal Delirium
Conditions
Interventions
Preoperative chemotherapy group:Preoperative neoadjuvant chemotherapy
control group:No chemotherapy before surgery
Sponsors
Jiangsu Cancer Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients with breast cancer who are planning to undergo radical mastectomy, unilateral/bilateral radical mastectomy with ipsilateral axillary lymph node dissection; 2. ASA grade: II-III; 3. 18.5kg/m2<BMI<30kg/m2; 4. Age 18-65 years old.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of severe neurological and psychiatric diseases, severe hearing/visual/speech dysfunction and unable to cooperate with relevant scale assessments; 2. Patients with a history of craniocerebral trauma or brain surgery within 3 months; 3. Patients who have taken sedatives, hypnotics or anticholinergics within 72 hours before and after surgery; 4. Patients with severe liver and kidney dysfunction, severe anemia, and severe hypoproteinemia; 5. Advanced patients with brain metastases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative subsyndromal delirium ;The incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative pain;TNF-a level in peripheral blood;IL-6;IL-8;Tau protein;Depth of intraoperative anesthesia; | — |
Countries
China
Contacts
Public ContactJianhua He
Jiangsu Cancer Hospital
Outcome results
None listed