Lung disease
Conditions
Interventions
IT group:Intrathecal injection of 0.25mg morphine and 3mg bupivacaine
Sponsors
The Affiliated Hospital of Yangzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients undergoing elective lung surgery; 2.18-65 years old, regardless of sex; 3.ASA I-III; 4.BMI18.5~30kg/m^2; 5.plan to stay in hospital for more than 48 hours after operation; 6.clearly understand and voluntarily participate in the study, and the informed consent form shall be signed by the person or his family member;
Exclusion criteria
Exclusion criteria: 1.patients with severe cardiac, liver and renal dysfunction before operation; 2.long-term use of analgesics, sedatives and alcoholism; 3.Intraspinal puncture is contraindicated; 4.suffered from severe neuropsychiatric diseases such as cerebrovascular disease, Alzheimer's disease, epilepsy and Parkinson's disease; 5.previous history of intracranial surgery or craniocerebral injury; 6.those with severe vision, hearing, language impairment or other reasons unable to communicate; 7.Patients with severe cognitive impairment with a score of 17 or lower on the Chinese version of the Mini-Mental State Examination (MMSE); 8.patients with allergy to morphine, local anesthetics, non-steroidal anti-inflammatory drugs (NSAID) or contraindications;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recovery quality 1 day after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Recovery quality 2 day and 3 day after surgery;Pain intensity at rest and during movement within 72 hours after surgery;The lowest and highest systolic blood pressure and highest heart rate during the operation;The time of the first remedy and the number of remedies;Total amount of opioids;Occurrence of adverse reactions;Postoperative recovery index;Postoperative complications;Chronic pain score;Sleep quality;Postoperative delirium;Homeostatic Model Assessment of Insulin Resistance; | — |
Countries
China
Contacts
Public ContactJangyou Zhang
The Affiliated Hospital of Yangzhou University
Outcome results
None listed