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Neoadjuvant Therapy's Impact on the Immune Microenvironment in Prostate Cancer

Neoadjuvant Therapy's Impact on the Immune Microenvironment in Prostate Cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400092934
Enrollment
Unknown
Registered
2024-11-26
Start date
2023-04-05
Completion date
Unknown
Last updated
2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

prostate cancer

Interventions

prostate cancer patient with neoadjuvant hormonal therapy:none
prostate cancer patient without neoadjuvant hormonal therapy:none

Sponsors

West China hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Patients in the high-risk prostate cancer (HRPCa) or locally advanced prostate cancer (LAPCa) stages who have received preoperative NHT (Neoadjuvant Hormonal Therapy); 2. Serum testosterone levels have reached castration levels; 3. Consent to participate in the clinical trial and have signed an informed consent form; 4. Expected life expectancy >3 months.

Exclusion criteria

Exclusion criteria: 1. History of autoimmune diseases or the need for systemic corticosteroid use; 2. Presence of severe heart, lung, liver, kidney, or hematological diseases; 3. Previous treatment with immune checkpoint inhibitors or neoadjuvant radiotherapy.

Design outcomes

Primary

MeasureTime frame
Progression-Free Survival;

Secondary

MeasureTime frame
Disease Control Rate;Pathological Response Rate;

Countries

China

Contacts

Public ContactQiang Dong

West China hospital, Sichuan University

dongqiang@scu.edu.cn+86 189 8060 1367

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026