Sedation of postoperative patients in ICU with mechanical ventilation
Conditions
Interventions
Ciprofol combined with dexmedetomidine group: Group CD:Group CD: Ciprofol combined with dexmedetomidine
Propofol combined with dexmedetomidine group: Group PD:Group PD: propofol combined with dexmedetomidine
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-70 years old; 2. Admitted to ICU with tube after surgery; 3. ASA Grading II-III; 4.BMI18-30kg/m^2; 5. Estimated tube time is 4-24h; 6. Sign the informed consent form
Exclusion criteria
Exclusion criteria: 1.Allergic to ciprofol or dexmedetomidine; 2. Admitted to ICU after operation with drugs to maintain the blood pressure; 3. Patients after neurosurgery; 4. Patients with psychiatric disorders (schizophrenia, mania) and cognitive dysfunction; 5. History of craniocerebral injury, intracranial hypertension, cerebral aneurysm, cerebrovascular accident and central nervous system disease; 6. Patients with sick sinus syndrome, bradycardia (heart rate less than 50 beats/min), atrioventricular block of 2 degrees or above, and no pacemaker implantation; 7. Severe liver dysfunction (Child-Pugh C), severe renal dysfunction ( dialysis patients before operation) 8. Conditions that other researchers did not consider appropriate for inclusion in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypotension in ICU patients with sedation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Maintenance dose, supplementary dose and total dose of propofol and ciprofol.;Extubation time after withdrawal; | — |
Countries
China
Contacts
Public ContactLifang Duan
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed