Thoracoscopic lung surgery
Conditions
Interventions
intercostal nerve block group (INCB group):Performing intercostal nerve block with liposomal bupivacaine under direct thoracoscopy at the end of the operation
erector spinae plane block group (ESPB group):Performing erector spinae plane nerve block with liposomal bupivacaine under ultrasound guidance at the end of the procedure
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.ASA class I-III; 2.Aged 18-75 years; 3.Subjects scheduled for elective video-assisted thoracoscopic lung surgery under general anesthesia with bronchial intubation.
Exclusion criteria
Exclusion criteria: 1.Subjects with sinus bradycardia (HR < 50 bpm) or heart conduction block (sinus block or atrioventricular block); 2.Subjects with left ventricular ejection fraction <40%; 3.Subjects with unstable coronary artery disease; 4.Subjects with hepatic or renal impairment (Child-Pugh class C or receiving renal replacement therapy); 5.Subjects with abnormal blood coagulation function; 6.Subjects with infection at the puncture site; 7.Subjects with a history of Parkinson's disease or Alzheimer's disease; 8.Subjects with a history of epilepsy; 9.Subjects are breast feeding and pregnant women; 10.Subjects with a history of chronic pain or preoperative use of sedatives or analgesics; 11.Subjects with a history of allergy to local anesthetic drugs or any of the experimental medications; 12.Subjects with diabetic neuropathy; 13.Subjects with neurological disorders (e.g., stroke, hypesthesia); 14.Subjects with uncontrolled psychiatric disorders (e.g., anxiety, depression, schizophrenia).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean NRS pain scores during rest at 24, 48, and 72 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS pain scores at rest and on activity at 24, 48 and 72 hours after surgery;Quality of recovery at 24, 48, and 72 hours after surgery;The total amount of opioid analgesics within 0-72 h postoperatively;The time to first press on the PCIA;Incidence of chronic pain at 90 days after surgery;Time to postoperative independent activities;Postoperative hospital stays; | — |
Countries
China
Contacts
Public ContactFuhai Ji
The First Affiliated Hospital of Soochow University
Outcome results
None listed