Autism spectrum disorder
Conditions
Sponsors
Binzhou Medical University Hospital
Eligibility
Sex/Gender
All
Age
3 Years to 17 Years
Inclusion criteria
Inclusion criteria: 1.Age 3-17 years; 2.Meets the diagnostic criteria for autism in the Diagnostic and Statistical Manual of Mental (5th Edition), with a total score =30 on the Childhood Autism Rating Scale (CARS) and a total score =67 on the Autism Checklist (ABC), clinically diagnosed with autism; 3.Agrees to collect stool samples and can make regular follow-up visits to the hospital.
Exclusion criteria
Exclusion criteria: 1. Combined with Reye's syndrome, 22q13 deletion syndrome and other genetic diseases that affect development; 2. History of previous brain organic diseases such as traumatic brain injury, cerebral palsy, encephalitis, etc.; 3. Family members with a history of severe mental illness or drug abuse; 4. Use of probiotics, antibiotics, antacids, etc. within 3 months prior to enrollment to affect intestinal flora; 5. Combined with organic intestinal lesions such as Hirschsprung's disease, intussusception, and intestinal obstruction; 6. Developmental quotient (DQ) score < 35 points; 7. Unable to tolerate colonoscopy or unable to cooperate with the placement of TET tubes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Autism Behavior Checklist (ABC); | — |
Secondary
| Measure | Time frame |
|---|---|
| 16S rRNA sequencing of intestinal flora; | — |
Countries
China
Contacts
Public ContactKun Li
Binzhou Medical University Hospital
Outcome results
None listed