disorders of consciousness
Conditions
Interventions
A:Parameter a: In each stimulus module, LIFUP performs stimulation under the following parameters: Pulse repetition rate (PRF) is 100 Hz, Pulse Duration (PD) is 0.5 ms, base frequency is 500kHZ, mecha
B:Parameter b: PRF is 5Hz, PD is 20ms, fundamental frequency(FF) is 500kHZ, PRP is 200ms, ISI is 200ms, pulse train repeat (PTR) is 400 times of pulse repetition. Total stimulation time is 80s. The t
GroupC:For the spurious stimulus group, use parameter a to set the parameters, but the transducer power is off.
Sponsors
Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center) ; Hangzhou Normal University.
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1)>28 days since injury or onset; 2)Age above 18y ; 3)Behavioral profile consistent with a VS/UWS or MCS, as assessed with the Coma Recovery Scale Revised; 4)Patients with no obvious disease fluctuation within a week.
Exclusion criteria
Exclusion criteria: 1)Without obvious heart diseases; 2)History of neurological illness prior to injury; 3) Inability to safely enter the MR environment; 4)Patients with skull defect in the left head; 5)Patients with intracranial metal implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coma Recovery Scale,CRS-R; | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting-state EEG;Functional magnetic resonance BOLD;PET-CT glucose metabolism signals; | — |
Countries
China
Contacts
Public Contactdihaibo;liuhongxiang
Hangzhou Normal University; Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center)
Outcome results
None listed