Effects of ultrasound-guided high ankle block combined with general anesthesia on postoperative cognitive function in fragile elderly patients based on the analysis of scale and EEG monitor

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400092882

Enrollment

Unknown

Registered

2024-11-25

Start date

2024-12-01

Completion date

Unknown

Last updated

2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative cognitive dysfunction

Interventions

High ankle block group:Ultrasound-guided high ankle block + general anesthesia was implemented for the HAB group on the affected side: Fifteen minutes before the induction of anesthesia, a high ankle

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age = 60 years old, good communication skills and can cooperate with the completion of various testing operations; 2.American Society of Anesthesiologists (ASA) grade I-III; 3.Preoperative Brief Mental State Examination Scale (MMSE) score, the normal boundary value division standard: illiterate (uneducated) group > 17 points, elementary school (= 6 years of education) group > 20 points, secondary school or above (> 6 years of education) group > 24 points; 4, Patients who underwent unilateral foot and ankle surgery; 5. Patients who meet the criteria for fragile brain function;

Exclusion criteria

Exclusion criteria: 1.BMI =40kg/m2; 2.History of allergy to local anesthetic and contraindication to nerve block anesthesia; 3.Those who suffer from serious heart, liver, lung, kidney and other vital organ diseases; 4.People with serious infection at the puncture site and obvious abnormality of coagulation function; 5.Cognitive or mental dysfunction resulting in the inability to communicate verbally for pain scoring; 6.Do not agree to participate in this study or sign the informed consent;

Design outcomes

Primary

Measure	Time frame
Neuropsychological Testing Portfolio;	—

Secondary

Measure	Time frame
Alpha relative power in occipital lobe;MoCA score;Patient stress indicators: levels of ACTH, NE, Ang-II, ß-EP, Glu, Cor;Patient VAS pain scores;Postoperative patient satisfaction scores;First time out of bed after surgery;Date of discharge;Incidence of postoperative adverse effects (headache, vomiting, urinary retention, hypotension);Occipital lobe alpha power;Burst suppression ratio in occipital lobe;	—

Measure

Time frame

Alpha relative power in occipital lobe;MoCA score;Patient stress indicators: levels of ACTH, NE, Ang-II, ß-EP, Glu, Cor;Patient VAS pain scores;Postoperative patient satisfaction scores;First time out of bed after surgery;Date of discharge;Incidence of postoperative adverse effects (headache, vomiting, urinary retention, hypotension);Occipital lobe alpha power;Burst suppression ratio in occipital lobe;

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Countries

China

Contacts

Public ContactWangKai

Xuzhou Central HospitalX

wangkaistream99@sina.com+86 181 1201 2729

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026