Knee Osteoarthritis
Conditions
Interventions
Group B:Oral nonsteroidal anti-inflammatory drugs (NSAIDs)
Group C:Ketoprofen cataplasms combined with oral nonsteroidal anti-inflammatory drugs (NSAIDs).
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1)Patients agree to participate in this study and sign a written informed consent form; (2)Aged 40~75 years old; (3) 18kg/m240mm; (5)Without the history of bleeding,asthma,severe heart\hepatic\renal insufficiency, non-steroida allergy, etc.; (6)The drugs used in experimental group and control group are contained in the drug list specified in this study.
Exclusion criteria
Exclusion criteria: (1)Previous treatment that may affect the drugs efficacy; (2)With open wounds, scars, or ulcers in the area where the gel patch is used; (3)With fractures, dislocations, etc.; with severe diseases such as tumors, cardiovascular and cerebrovascular diseases, and hematopathy,with mental illness and communication disorders that efficacy cannot be determined.Additionally pain and mobility disorder related to other conditions(eg,internal organs lesion,cardiovascular and cerebrovascular diseases ) .Allergy to this class of non-steroidal drugs; (4)Pregnant, Lactating women,or women of childbearing age who are preparing to conceive; (5)With other conditions that the researchers deems inappropriate to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Western Ontario and McMaster University Osteoarthritis Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale ;Percentage of subjects with WOMAC pain subscale decreased from baseline by =30%, =50%, =70%, and =90% ;Proportion of subjects responding to OMERACT-OARSI;Lysholm Knee Scoring Scale;Paracetamol tablet usage;Comfort of cataplasms;Satisfaction surveys; | — |
Countries
China
Contacts
Public ContactHui Li
The Second Xiangya Hospital of Central South University
Outcome results
None listed