Parkinson’s disease
Conditions
Interventions
active group:The conditioned stimulus intensity is set at 90% of the resting motor threshold (RMT), while the test stimulus intensity is set at 140% of the RMT. The stimulation interval is 6 milliseco
Control group:NA
Sponsors
Beijing Tiantan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria for patients with Parkinson's Disease (PD) are as follows: 1. Patients who meet the diagnostic criteria established by the International Association of Movement Disorders (MDS) in 2015. 2. Hoehn and Yahr (H-Y) stages ranging from 1 to 3. 3. No changes in PD-related pharmacotherapy. 4. Agreement to participate in a total of three resting-state functional magnetic resonance imaging (rs-fMRI) scans. 5. Presence of tremor symptoms; The MDS Unified Parkinson Disease Rating Scale (MDS-UPDRS) tremor score/gait posture score is >= 1.15; 6. Signing of the informed consent form. 7. Exclusion of patients whose spouses are also diagnosed with PD or a related disorder. Selection of the control group: Spouses of PD patients who do not exhibit any motor disorders and do not meet the exclusion criteria.
Exclusion criteria
Exclusion criteria: The exclusion criteria for all subjects are as follows: (1) Patients with unclear diagnoses or suspected Parkinson's syndrome; (2) Patients with a history of stroke, head trauma, hydrocephalus, brain tumors, increased intracranial pressure, or intracranial surgery; (3) Patients with metal foreign bodies, pacemakers, or cochlear implants; (4) Individuals unable to cooperate with resting-state fMRI scanning; (5) Mini Mental State Examination (MMSE) score of <= 24; (6) Individuals experiencing hearing changes, seizures, fainting, severe headaches, or other adverse reactions during assessment; (7) Patients with a history of epilepsy; (8) Patients with alcohol or central nervous system drug dependence; (9) Sleep deprivation, unresolved jet lag, or excessive fatigue; (10) Medication-induced tremors (e.g., from levonorgestrel); (11) Pregnant women; (12) Patients with severe or recent cardiovascular or cerebrovascular diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MDS-UPDRS-?; | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional connectivity;amplitude of low frequency fluctuation,ALFF;17-Hamilton Depression Scale;Hamilton Anxiety Scale; | — |
Countries
China
Contacts
Public ContactTao Feng
Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Outcome results
None listed