elderly patients undergoing major abdominal surgery
Conditions
Interventions
experimental group:After the patients were transferred to the ICU postoperatively, they were immediately given dexmedetomidine (Approval No.: H20110085, Manufacturer: Jiangsu Nhwa Pharmaceutical Co.,
control group:After the patients were transferred to the ICU postoperatively, they were given dexmedetomidine (as above) in combination with remifentanil (Approval No.: H20143314, Manufacturer: Jiangs
Sponsors
Northern jiangsu people’ hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age >= 65 years. (2) Duration of abdominal surgery >=2 hours and requiring postoperative mechanical ventilation. (3) Obtained consent from the patient and their family, with an informed consent form signed.
Exclusion criteria
Exclusion criteria: (1 )History of allergy to relevant medications. (2) Presence of mental disorders. (3) History of opioid dependence or long-term use of analgesic medications. (4) Hemodynamic instability, with systolic blood pressure (SBP) 18 µg/min). (5) History of arrhythmia-related conditions or patients with a pacemaker. (6) Patients who refuse to participate in this study or are currently participating in other studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| duration of mechanical ventilation;time to achieve analgesic goals;IL-6;TNF-a; | — |
Countries
China
Contacts
Public ContactRuiqiang Zheng
Northern jiangsu people’ hospital
Outcome results
None listed