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Effect of S-ketamine on depression, inflammation and brain MRI after abdominal surgery in depressed patients

Effect of S-ketamine on depression, inflammation and brain MRI after abdominal surgery in depressed patients

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400092868
Enrollment
Unknown
Registered
2024-11-25
Start date
2024-11-25
Completion date
Unknown
Last updated
2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative sleep disorders

Interventions

Experimental group (esketamine group):Ace ketamine
Control group (saline group):equivalent amount of saline

Sponsors

General Hospital of the Eastern Theatre of the Chinese People's Liberation Army
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Age =18 years (2) Elective general surgery under general anaesthesia (3) ASA grade ?~?

Exclusion criteria

Exclusion criteria: (1) Allergy to anaesthetic drugs used or ketamine (2) Other types of sleep disorders, such as OSA, restless legs syndrome or periodic limb movement disorders (3) Uncontrolled high blood pressure (4) Heart failure, coronary artery disease or hyperthyroidism (5) Chronic opioid therapy (more than twice a week for more than three months) (6) Inability to understand rating scales

Design outcomes

Primary

MeasureTime frame
Sleep quality score ;

Secondary

MeasureTime frame
Quality of postoperative recovery;Hospital Anxiety Depression Score;Pain scores;Postoperative opioid consumption;

Countries

China

Contacts

Public ContactQing Ji

General Hospital of the Eastern Theatre of the Chinese People's Liberation Army20

qing_ji@nju.edu.cn+86 139 1391 5619

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026