Alzheimer's Disease
Conditions
Interventions
Intervention group:music therapy+ conventional treatment
control group:conventional treatment
Sponsors
Tianjin Huanhu Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 90 Years
Inclusion criteria
Inclusion criteria: a)Intervention group: Age 50-90 years old, male or female; Patients with MCI due to AD and mild AD are clearly diagnosed according to the NIA-AA core clinical criteria for moderate probable AD and probable AD. PET or plasma tests are positive for Amyloid ß; The overall CDR score is 0.5 to 1.0; Patients can complete the scale assessment and MRI examination; The subjects should have stable and reliable caregivers, or at least have frequent contact with caregivers (at least 3 days per week and at least 2 hours per day), who will assist the patients in participating in the entire study process. Caregivers must accompany the subjects during research visits and assist them in completing scales such as NPI and other scale scores;b) Control group: Patients with diagnosis of MCI due to AD and mild AD during the same period; Sex, age, and years of education are matched to the intervention group; Results of the MMSE and CDR measures are matched to the intervention group; Scale evaluations and MRIs can be completed in cooperation with the group; There is a stable and reliable caregivers can complete scale scores such as NPI and other scale scores;
Exclusion criteria
Exclusion criteria: a) Dementia or PD caused by other central nervous system diseases, such as vascular dementia, frontotemporal dementia, central nervous system infection, multiple sclerosis, epilepsy, normal cranial pressure hydrocephalus, traumatic brain dementia, intracranial space occupying lesions, etc.; b) History of stroke in key areas, or MRI findings of infarction or bleeding in key areas such as hippocampus, thalamus, olfactorium, suproccipital gyrus, middle occipital gyrus, corneal gyrus, cortex and other subcortical gray matter masses, or leukodystrophy with Fazekas score =2; c) Systemic diseases that may lead to dementia or secondary PD, Such as serious heart and lung, liver and kidney function diseases, autoimmune diseases, blood diseases, endocrine system diseases (such as thyroid disease, parathyroid disease), nutritional factors (such as vitamin, folic acid deficiency), toxic diseases (such as drug poisoning, alcoholism, carbon monoxide poisoning), infectious factors (such as syphilis, HIV), etc.; d) Patients with severe mental illness (such as severe depression, schizophrenia, etc.), such as HAMD=8 points; e) Severe visual and hearing impairment, aphasia, and poor physical activity, which lead to inability to complete the neuropsychological scale assessment; f) Patients who are allergic to contrast media, claustrophobic and can not tolerate long-term MRI examination; g) Caregivers who care for less than 2 hours a day
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropsychological scale assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| ApoE gene;Plasma biomarker; | — |
Countries
China
Contacts
Public ContactShuai Liu
Tianjin Huanhu Hospital
Outcome results
None listed