Hepatocellular carcinoma
Conditions
Interventions
Experimental group:Through preoperative CT hepatic vascular 3D imaging and color Doppler ultrasound, the subsegmental hepatic pedicle of the tumor-bearing liver was highly selectively searched and loc
Control group:Ultrasound-guided electrode needle was directly punctured into the tumor for radiofrequency ablation in a conventional way.
Sponsors
Southwest Hospital, Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.The research object understands the research content and significance, and obtains written informed consent; 2.Gender is not limited, age = 18 years old, = 75 years old; 3.Patients had a history of HCC resection or RFA, and the clinical or pathological diagnosis of HCC was obtained according to the American ASSLD standard. The number of lesions was 1; the maximum lesion = 3cm, with enhanced CT or enhanced MRI as the standard; 4.Patients who could not or did not want to undergo resection again; 5.Child Pugh A (= 7 points), no need for treatment of pleural effusion and ascites and hepatic encephalopathy; the Eastern Cooperative Oncology Group (ECOG) behavioral status score was 0-1; 6.Within 7 days before enrollment, there were enough liver and kidney function, appropriate laboratory indicators ( untreated ) : hemoglobin ( HGB ) = 9.0g / dl, neutrophils = 1,500 / mm3, PLT = 50 × 109 / L, serum ALB = 28g / L, TBIL < 50umol / L, ALT, AST < 5 times the upper limit of normal value, Bun, Cr < 1.5 times the upper limit of normal value, INR < 1.7 or PT extension < 4s; 7.The tumor was located in the liver parenchyma, and there was a needle path through the liver parenchyma. There were no large blood vessels, bile ducts and important organs around the tumor; 8.No other anti-tumor treatment was received before operation.
Exclusion criteria
Exclusion criteria: 1.Serious heart and lung disease ; bleeding, coagulation dysfunction; portal hypertension; pregnancy; 2.ASA score: > 3; 3.Epilepsy, psychiatric patients; 4.Preoperative imaging showed that the lesion was close to the surface of the liver, gallbladder, important blood vessels in the hepatic portal, bile duct and surrounding important organs. It is expected that the operation may cause serious accidental injury and serious complications; 5.Clear extrahepatic metastasis and hepatic vascular tumor thrombus.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 2-year overall survival ;2-year recurrence-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative complication;Postoperative liver function; | — |
Countries
China
Contacts
Public ContactHuaqiang Bi
Institution of Hepatobiliary Surgery, Southwest Hospital, Army Medical University
Outcome results
None listed