idiopathic nephrotic syndrome
Conditions
Interventions
Remission group/ Non-remission group:none
Sponsors
Shenzhen Second People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1) Primary nephrotic syndrome (MCD, IMN); 2) older than 18 years old; 3) the eGFR > 40 ml/min, urine protein > 3.5 g/d , albumin <30 g/L; 4) no use of hormone and immune inhibitors and previous history of RTX; 5)Voluntary informed consent signed enters.
Exclusion criteria
Exclusion criteria: 1) secondary nephrotic syndrome patients; 2) with lymphoma, SLE, RA, diseases such as hepatitis b, hepatitis c, HIV patients; 3) RTX or mouse protein allergy; 4) patients with severe active infection; 5) immune response to severe damage, such as low gamma globulin hematic disease, severe CD4 / CD8 cells number decrease) patients. 6) patients with severe heart failure (NYHA class ?); 7) patients treated with corticosteroids and immunosuppressants (including CNI, CTX) or RTX; 8) pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whether there is relief, whether there is recurrence after relief, the time and frequency of the first recurrence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Relief rate, recurrence rate, and number of B cell subpopulations; | — |
Countries
China
Contacts
Public ContactHaiYing Song
Department of Nephrology, Shenzhen Second People's Hospital
Outcome results
None listed