Posteroperative nause and vomiting
Conditions
Interventions
PONV group:NA
No PONV group:NA
Sponsors
Beijing Friendship Hospital of Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.The subjects agreed to accept oral swab collection, fully understood the purpose and significance of this trial, signed the informed consent form voluntarily, and voluntarily complied with the trial process; 2.Elective laparoscopic bariatric surgery under general anesthesia; 3. Age 18-60 years old; 4. BMI>=30kg/m^2; 5. American Society of Anesthesiologists (ASA) grade I-III; 6.Subjects voluntarily used patient-controlled intravenous analgesia (PCIA) for 24-48 hours with sufentanil after extubation.
Exclusion criteria
Exclusion criteria: 1. Complicated with important organ diseases or serious systemic diseases; 2. History of vestibular disease or dizziness, digestive tract, central nervous system and other system diseases that may cause nausea and vomiting; 3. History of chronic pain requiring long-term use of analgesic or sedative drugs; 4.Combined with mental illness or cognitive impairment, unable to communicate well; 5. Subjects were expected to be transferred to ICU with an endotracheal tube after operation 6. Subjects who participated in other clinical trials within the past 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| posteroperative nause and vomiting;CHRM3 rs2165870 Genotypes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Posteroperative nause and vomiting;KCNB2 rs349358 Genotypes;COMT rs4680 Genotypes;ABCB1 rs1045642 Genotypes;Use of postoperative rescue antiemetics;Use of postoperative rescue analgesics;Use of postoperative patient-controlled intravenous analgesia ;Intraoperative consumption of sufentanil;NRS(Numerical Rating Scale) pain score;NRS(Numerical Rating Scale) pain score;NRS(Numerical Rating Scale) pain score; | — |
Countries
China
Contacts
Public ContactHao Dandan
Beijing Friendship Hospital of Capital Medical University
Outcome results
None listed