Analgesics-sedatives
Conditions
Interventions
Control group (midazolam group):Administer midazolam slowly via bolus injection at a dose of 1-3 mg, and if the procedure exceeds 20 minutes, administer an additional 1-3 mg of midazolam.
Sponsors
Shandong University Qilu Hospital (Qingdao)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) 18 years old <= age <80 years old; (2) Patients admitted to the ICU who require tracheal intubation and ventilator-assisted ventilation, and who also need to undergo fiberoptic bronchoscopy; (3) Obtaining informed consent from the patient or their family members.
Exclusion criteria
Exclusion criteria: (1) Pregnant or lactating women; (2) Patients with a history of drug abuse, addiction, alcoholism, or long-term use of psychotropic drugs within the past 2 years before screening, or patients with chronic pain requiring long-term opioid use; (3) Patients in the terminal stage of cancer or with multiple organ failure with an expected survival time of less than 48 hours; (4) Patients with any condition that impairs the correct assessment of cognitive function, such as brain injury, stroke, brain tumor, central nervous system infection, epilepsy, as well as language and sensory impairments or mental disorders (e.g., difficulty in speaking or severe organic mental dysfunction); (5) Participation in other exploratory clinical trials within 6 months prior to screening; (6) Inability to obtain informed consent or authorization; (7) Patients allergic to the test drugs or their excipients; (8) Severe liver impairment (Child-Pugh Class C or higher); (9) Chronic renal insufficiency or severe acute renal injury (KDIGO Stage II or higher); (10) Presence of arrhythmias, acute myocardial infarction, or severe cardiac insufficiency (NYHA Class III or higher).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| heart rate;mean arterial pressure;respiratory rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| duration of mechanical ventilation; | — |
Countries
China
Contacts
Public ContactGuo Xi
Shandong University Qilu Hospital (Qingdao)
Outcome results
None listed