Prevention of periprosthesis joint infection after aseptic revision
Conditions
Interventions
Control group (standard prevention):1.Preoperatively: prophylactic intravenous 1.5g of cefuroxime sodium was given within 1 hour prior to surgical skin incision. 2.Postoperative: Prophylactic intraven
Test group (extended oral prophylaxis):1.Preoperatively: prophylactic intravenous 1.5g of cefuroxime sodium was given within 1 hour prior to surgical skin incision. 2.Postoperative: Prophylactic intra
Sponsors
First Affiliated Hospital of Xinjiang Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Undergoing revision surgery for artificial joints due to aseptic failure; (2) between the ages of 18 and 90 (inclusive), regardless of gender; (3) The subject agrees and signs an informed consent form approved by the Ethics Committee prior to any research procedure; (4) The subject is willing and able to participate in the prescribed follow-up visit and is able to complete the study activities.
Exclusion criteria
Exclusion criteria: (1) The diagnostic criteria for periprosthesis joint infection after arthroplasty in 2018 International consensus meeting; (2) The subject has a clear history of allergy to fluoroquinolones, cephalosporins; (3) Pregnant, parturient and lactating women; (4) Combined with bone tumors or other malignant tumors; (5) the subject is unable to tolerate the operation due to other medical conditions; (6) the subject is participating in other clinical trials; (7) The investigator believes that the subject has other diseases or conditions that are not suitable for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of infection; | — |
Secondary
| Measure | Time frame |
|---|---|
| HSS;Harris score;SF-12;VAS;Time interval between infections;Reoperation rate;CRP;ESR; | — |
Countries
China
Contacts
Public ContactLi Cao
The First Affiliated Hospital of Xinjiang Medical University
Outcome results
None listed