cognitive dysfunction after brain injury
Conditions
Interventions
Test group:Basic treatment + Huperzine A injection
Control group:Basic treatment + Placebo (saline)
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Age 18-70 years; 2.Patients with definite etiology, clinical manifestations, laboratory tests, imaging consistent with diagnosis of brain injury; 3.Patients or their legally significant guardians signed Informed Consent Form prior to the trial; 4.Patients diagnosed with postoperative memory impairment;
Exclusion criteria
Exclusion criteria: 1.History of psychiatric disorders, chronic use of sedatives, antidepressants, etc. 2.History of alcohol and drug abuse; 3.Severe systemic diseases, especially circulatory system diseases: such as history of myocardial infarction, heart failure, unstable angina pectoris, sinus bradycardia; 4.Inability to tolerate the test or cooperate with the examiner due to various reasons, various aphasia, audiovisual dysfunction, etc. 5.Patients with angina pectoris, bronchial asthma, mechanical ileus, hepatic and renal dysfunction, urinary tract obstruction, epilepsy; 6.Taking other cholinesterase inhibitor medications; 7.Pregnant or lactating women, and women of childbearing potential not practicing reliable contraception with no evidence of negative pregnancy; 8.Allergy to investigational drugs; 9.Participated in other clinical trials within the past 3 months; 10.Patients considered inappropriate for participation in the clinical trial by the investigator;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function score; | — |
Secondary
| Measure | Time frame |
|---|---|
| MFI score;GCS score;KPS score;Occurrence of pituitary hypothalamic dysfunction;Occurrence of organ disorders; | — |
Countries
China
Contacts
Public ContactSongtao Qi
Southern Medical University Southern Hospital
Outcome results
None listed