Esophageal cancer
Conditions
Interventions
PEEP INCREMENTAL:During thoracoscopy and laparoscopy, PEEP titration is applied, starting from 0cm H2O and increasing by 1cmH2O each time, up to a maximum of 20cmH2O. Each PEEP level lasts for 5 respi
PEEP DECREMENTAL:During thoracoscopy and laparoscopy, PEEP titration is applied, starting from 20cm H2O and decreasing by 1cmH2O each time. Each PEEP level lasts for 5 respiratory cycles, and the driv
PEEP tidal volume:Drive pressure guide tidal volume control ventilation
PEEP of 5 cmH2O:The patient had a fixed PEEP of 5cmH2O throughout the entire surgical period, with tidal volume of 6ml/kg during one lung ventilation and tidal volume of 8ml/kg during two lung ventila
Sponsors
The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: ? Age:18-75 years;?BMI=18.5-25kg/m2;? ASA:I-III;? time of one lung ventilation>1 hour;? Approved by the hospital ethics committee, the researcher agrees to sign a written consent form to participate in this study.
Exclusion criteria
Exclusion criteria: ? Patients with severe cardiovascular disease or severe liver and kidney dysfunction; ? History of serious complications in the past includes pulmonary infection, pleural effusion, atelectasis, respiratory failure, and cardiogenic pulmonary edema Contraindications for the use of positive end expiratory pressure (tension pneumothorax, pulmonary bullae, severe barotrauma, hypovolemic shock, bronchopleural fistula, high intracranial pressure); ? Intraoperative massive bleeding (greater than 500ml); ? Hemodynamic instability
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Atelectasis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Oxygenation index;Peak airway pressure;plateau pressure;end-expiratory positive pressure;Driving pressure;Pulmonary compliance;mean arterial pressure ;Heart rate;pulse oxygen saturation;Post-operative pulmonary complications; | — |
Countries
China
Contacts
Public ContactSu Zhen
The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University
Outcome results
None listed