Chronic Obstructive Pulmonary Disease
Conditions
Interventions
Chronic Obstructive Pulmonary Disease (COPD) patient group:NA
Healthy control group:NA
Sponsors
Beijing Friendship Hospital ,Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria for the COPD patient group 1) The COPD patient group meets the diagnostic criteria for COPD promulgated by the Global Initiative for Lung Disease (GOLD); 2) No serious neurological diseases (e.g., cerebral hemorrhage, intracranial tumors, Parkinson's syndrome, cerebral infarction, Alzheimer's disease, hereditary cerebral small-vessel disease, amyloidosis cerebriocephaly, central nervous system vasculitis, inherited and acquired cerebral white matter demyelinating disease, etc.); 3) no serious other physical diseases (such as malignant tumors, heart disease and renal failure, etc.); 4) no history of craniocerebral trauma, surgery, drug and alcohol dependence; 5) no history of current or past psychiatric disorders; 6) subjects voluntarily signing the informed consent form and having good compliance. Inclusion criteria for healthy controls 1) Healthy controls did not meet the diagnostic criteria for COPD promulgated by the Global Initiative for Lung Disease (GOLD), and were roughly matched to the group of patients with COPD in terms of age, gender, and education; 2) No serious neurological diseases (e.g., cerebral hemorrhage, intracranial tumors, Parkinson's syndrome, cerebral infarction, Alzheimer's disease, hereditary cerebral small-vessel disease, amyloidosis, cerebrovascular disease, central nervous system disease, and other neurological disorders). cerebrovascular disease, central nervous system vasculitis, hereditary and acquired cerebral white matter demyelinating disease, etc.); 3) no serious other physical diseases (such as malignant tumors, heart disease and renal failure, etc.); 4) no history of craniocerebral trauma, surgery, drug and alcohol dependence; 5) no history of current or past psychiatric illnesses; 6) subjects voluntarily signing an informed consent form and having good compliance.
Exclusion criteria
Exclusion criteria: 1) Contraindications to magnetic resonance examination; 2) Poor cooperation during MRI scanning and image artifacts for various reasons; 3) Fazekas classification of cerebral white matter lesions higher than grade 2; 4) Adults who are not capable of giving informed consent due to cognitive impairment or health conditions; 5) Those who voluntarily abandoned the examination for various reasons during the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tidal volume (VT);Residual volume (RV);Total lung capacity (TLC);First-second expiratory volume with exertion (FEV1);First-second expiratory volume with exertion to forceful lung volume ratio (FEV1/FVC);Diffusing capacity for carbon monoxide (DLCO); | — |
Secondary
| Measure | Time frame |
|---|---|
| Aberrant amplitude low-frequency fluctuation (ALFF);Regional homogeneity (ReHo);gray matter volume;white matter integrity;Beck's Depression Inventory;State-Trait Anxiety Inventory;Montreal Cognitive Assessment (MoCA); | — |
Countries
China
Contacts
Public ContactQian Chen
Beijing Friendship Hospital ,Capital Medical University
Outcome results
None listed