Herpes Zoster Neuralgia
Conditions
Interventions
Healthy group:None
Herpes zoster group:None
Healthy group:Blood Draw Upon Admission
Herpes zoster group:Blood Draw Upon Admission
Postherpetic neuralgia group:Blood Draw Upon Admission
Sponsors
Affiliated Hospital of Traditional Chinese Medicine of Southwest Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ? Healthy individuals,patients with herpes zoster accompanied by pain within 1 month of onset,and patients with postherpetic neuralgiapain duration1 month;? Age range from 18 to 80 years oldincluding 18 and 80;? Body Mass IndexBMIbetween 18.0 and 30.0including 18.0 and 30.0;? Willing to participate in this study,complete all study assessments,and sign an informed consent form.? Inclusion criteria for basic information statisticsI.Normal individualsPatients are from the physical examination center and are diagnosed with no underlying diseases by the center;II.Herpes zoster patientsPatients are from the pain department,with initial herpes or pain diagnosed within 1 month of onset;III.Postherpetic neuralgia patientsPatients are from the pain department,with initial herpes or pain diagnosed more than 1 month after the onset of herpes zoster;PHN patients are divided into radiofrequency ablation group and spinal cord stimulation group based on different treatment methods.? Inclusion criteria for blood collection and mononuclear cell and transcriptome gene sequencing,all cases are from the previously included cases for basic information statistics.I.Normal individualsPatients are from the physical examination center and are diagnosed with no underlying diseases by the center;II.Herpes zoster patientsPatients are from the pain department,with initial herpes or pain diagnosed within 1 month of onset,and have not undergone regular standardized treatment such as analgesics or antiviral therapy;III.Postherpetic neuralgia patientsPatients are from the pain department,with initial herpes or pain diagnosed more than 1 month after the onset of herpes zoster,and have not undergone regular standardized treatment such as analgesics or antiviral therapy since the onset of herpes zoster neuralgia.
Exclusion criteria
Exclusion criteria: ? Individuals with severe cardiopulmonary,hepatic,or renal diseasessuch as hypertension stage 3 or above,heart failure,coronary heart disease,severe unstable cardiovascular diseases,acute myocardial infarction,sinoatrial node dysfunction,pulmonary embolism,respiratory failure,chronic renal failure,severe liver dysfunction;? Individuals with hematological disorders;? Individuals with a history of severe mental illness or long-term use of psychoactive substancessuch as epileptic seizures;? Non-cooperative individuals,such as those with concurrent neurological or psychiatric disorders,or those unwilling to cooperate;? Individuals with infectious diseasesi.e.,HIV,hepatitis B,syphilis;? Individuals with malignant tumors;? Pregnant or breastfeeding women;? Individuals with secondary bacterial infections;? Individuals who have received immunosuppressive treatment or corticosteroid treatment before inclusion in the trial;? Individuals who are currently participating in or have participated in other clinical trials within 12 weeks before the trial;and others deemed unsuitable to participate in the clinical trial by the researchers judgment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hospital Discharge Pain Scale Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospital Admission Pain Scale Score;After Treatment Pain Scale Score; | — |
Countries
China
Contacts
Public ContactZhang Ying
Affiliated Hospital of Traditional Chinese Medicine of Southwest Medical University
Outcome results
None listed