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Effect of rosuvastatin on QT interval in human

Effect of rosuvastatin on QT interval in human-a prospective randomized controlled trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400092701
Enrollment
Unknown
Registered
2024-11-21
Start date
2023-08-21
Completion date
Unknown
Last updated
2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abnormal electrocardiogram activity and arrhythmia

Interventions

Intervention group,:10mg rosuvastatin
control group:20mg atorvastatin

Sponsors

Ningbo Medical Centre Lihuili Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Patients suspected of coronary heart disease and planning to use statins 2. Subjects who are not critically ill and may be life-threatening 3. Participants agreed to participate in this experiment and signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1: Statins were used before admission. 2: Patients who used other drugs leading to prolonged QT interval before admission or had plans to use such drugs after admission. 3: Patients with previous history of cardiac ion channel disease, torsade de pointes or sudden cardiac death. 4: Patients with severe hepatic and renal insufficiency and contraindications for statin use.

Design outcomes

Primary

MeasureTime frame
Torsades de pointes;

Secondary

MeasureTime frame
Newly emerged QT prolongation;Increased QTc interval;

Countries

China

Contacts

Public ContactZhu Lijun

Ningbo Medical Centre Lihuili Hospital

zljun1222@163.com+86 187 5756 7614

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026