none
Conditions
Interventions
Pro-Xylane anti-wrinkle milk group:Apply Pro-Xylane anti wrinkle lotion in the morning and evening every day, pay attention to sun protection, and use continuously for 56 days.
Postbiotics anti-wrinkle milk group:Apply Postbiotics anti wrinkle lotion once a day in the morning and once in the evening, pay attention to sun protection, and use continuously for 56 days.
control group:Apply control products once a day in the morning and once in the evening, pay attention to sun protection, and use continuously for 56 days.
Sponsors
Dermatology Hospital of Southern Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Age range: 20-60 years old (with 75 people aged 20-40 and 75 people aged 40-60), in good health condition; (2) Dry skin (two groups of dry skin, with Pro-Xylan group randomly assigned to dry or oil); (3) Large pores; (4) Dark skin tone; (5) There are obvious wrinkles on the face; (6) There are obvious pigmentation on the face; (7) Able to understand the experimental process, voluntarily participate in the experiment and sign a written informed consent form, willing to actively cooperate in completing the research content and maintain a healthy and regular lifestyle during the research period.
Exclusion criteria
Exclusion criteria: (1) Individuals with sensitive facial skin; (2) Individuals who have received botulinum toxin injections, filling or whitening injections, Thermage, laser, radio frequency, and other medical beauty treatments in the past 6 months; (3) Those who have used any topical medication at the test site within the past two months; (4) Those who have used antihistamines in the past week or immunosuppressants, antibiotics, or hormone drugs within the past month; (5) Patients with inflammatory skin disease who have not yet recovered clinically; (6) Insulin dependent diabetes patients; (7) Asthma or other chronic respiratory disease patients undergoing treatment; (8) Individuals who have received anti-cancer chemotherapy within the past six months; (9) Patients with immunodeficiency or autoimmune diseases; (10) Pregnant, currently preparing for pregnancy, breastfeeding, or having given birth in the past 12 months; Or those who have a history of taking oral contraceptives within the past month; (11) Have experienced drug and alcohol dependence in the 12 months prior to the start of the study; (12) Have a history of chronic or serious diseases such as heart, liver, kidney, digestive tract, nervous system, reproductive system, mental and metabolic abnormalities; (13) Those who have obvious scars, pigmented nevi, atrophy, bright red nevi, sunburn, wounds, abrasions, tattoos, or other defects in or near the skin test site that affect the determination of test results; (14) Individuals who have participated in similar facial trials, oral drug trials, or other clinical trials within the past two months; (15) Individuals with high physical sensitivity; (16) Individuals who are known to be allergic to ingredients in cosmetics or daily chemical products, alcohol, rubber, or drugs; (17) Those who need to be exposed to outdoor sunlight for a long time due to work or other reasons; (18) Individuals with other iatrogenic issues that may affect the trial results (such as a history of coagulation dysfunction, severe hyperglycemia, hypertension, hyperlipidemia, mental illness, or other major illnesses); (19) Non voluntary participants or those who are unable to complete the prescribed experimental content as required.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Facial image uptake and analysis;Image analysis of facial wrinkles and analysis;The measurement of transepidermal water loss;The measurement of Stratum corneum;Determination of skin grease;The measurement of skin elasticity ;The measurement of skin firmness;Self-assessment of subject; | — |
Secondary
| Measure | Time frame |
|---|---|
| The measurement of skin pH; | — |
Countries
China
Contacts
Public ContactYe Li
Dermatology Hospital of Southern Medical University
Outcome results
None listed