delirium
Conditions
Interventions
Dexmedetomidine group :Dexmedetomidine was instilled intravenously 15 minutes before anesthesia induction, and dexmedetomidine 0.4 µg/kg/h was continuously pumped intravenously after induction, and th
Control group:15 minutes before anesthesia induction, an equal dose of normal saline is infused intravenously as a loading dose, and an equal dose of normal saline is continuously infused intravenousl
Sponsors
the First Affiliated Hospital of Soochow University,Suzhou
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Sign the informed consent form (2) Age >=65 years old (3) ASA Grades II–III; (4) Patients undergoing radical resection of gastrointestinal tumors under general anesthesia. (5) Fried scored 3 points
Exclusion criteria
Exclusion criteria: (1) Patients with severe cardiac, hepatic and renal insufficiency; (2) Preoperative delirium or dementia (3) Inability to enter into verbal communication (4) Failure to sign informed consent; (5) Severe bradycardia (resting heart rate <50 beats/min); (6) Known intolerance or hypersensitivity to dexmedetomidine; (7) History of traumatic brain injury or neurosurgical treatment; (8) History of psychotropic drug use;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Interleukin 6;C-reactive protein;First time of passing gas through the anus;Postoperative sleep score for 1 to 5 days;Postoperative nausea and vomiting score from 1 to 5 days;Pain score 1-5 days after surgery;Recovery quality score on the first day after surger; | — |
Countries
China
Contacts
Public ContactWang Yulan
the First Affiliated Hospital of Soochow University,Suzhou
Outcome results
None listed