Acute myeloid leukemia
Conditions
Interventions
Trial group:Low-dose monotherapy of venetoclax
Sponsors
Department of Hematology of Anhui Provincial Hospital, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
14 Years to No maximum
Inclusion criteria
Inclusion criteria: A. Patients with acute myeloid leukemia (other than acute promyelocytic leukemia) confirmed by bone marrow examination, who had completed induction and consolidation chemotherapy, remained in residual disease-negative complete remission (CRMRD-) as assessed before enrollment, and were ineligible or unwilling to undergo hematopoietic stem cell transplantation. B. over 14 years old, regardless of gender or race; C. Physical status: ECOG score 0-3; D. Cardiac function: left ventricular ejection fraction = 40%; E. Expected survival time > 12 weeks; F. Serum creatinine (Cr) =1.5×ULN (upper limit of normal), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =2.5×ULN, total bilirubin =1.5×ULN; G. The patient is self-aware and able to sign informed consent; The guardian of the child patient agreed to sign the informed consent. F. Lactating women were required to discontinue breastfeeding to participate in the study
Exclusion criteria
Exclusion criteria: A. Except for patients with non-remission of the primary disease or positive residual disease; B. Pregnant women, women who do not agree to stop breastfeeding during lactation; C. active HBV or HCV infection; D. People living with HIV;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| leukemia-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall?Survival;Duration of Overall Response;The incidence of adverse effects; | — |
Countries
China
Contacts
Public ContactJuan Tong
Department of Hematology of Anhui Provincial Hospital, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
Outcome results
None listed