mild cognitive impairment of intracranial tuberculosis
Conditions
Interventions
Gold Standard:Acid-fast bacilli were found in cerebrospinal fluid (CSF), mycobacteria culture was positive in CSF, and nucleic acid detection of Mycobacterium tuberculosis was positive in CSF.
Index test:Diagnosis and prediction model of mild cognitive impairment in patients with intracranial tuberculosis
Sponsors
Beijing Chest Hospital,Capital Medical University
Eligibility
Sex/Gender
All
Age
16 Years to 70 Years
Inclusion criteria
Inclusion criteria: Admission criteria for patients with intracranial tuberculosis: 1. Accord with at least 1 of the following clinical manifestations:headache, irritability, vomiting, fever, neck stiffness, convulsions, local nerve damage, disturbance of consciousness, lethargy, have one or more of the following at the same time: Acid fast bacilli were found in cerebrospinal fluid (CSF); Positive culture of mycobacteria in CSF; Positive nucleic acid test of Mycobacterium tuberculosis in CSF. 2. Tuberculous pathological changes were found in the brain or spinal cord, acid-fast staining was positive, and there were clinical manifestations and corresponding CSF changes. Admission criteria for patients with occult infection of intracranial tuberculosis: 1. Patients with hematogenous disseminated pulmonary tuberculosis have no neurological symptoms, such as headache, irritability, vomiting, neck stiffness, convulsions, local nerve damage, disturbance of consciousness, lethargy. 2. No abnormality in cerebrospinal fluid test: no acid-fast bacilli in CSF, negative culture of mycobacteria in CSF, negative nucleic acid test of Mycobacterium tuberculosis in CSF. 3. No abnormalities were found on conventional MRI, but those with concealed lesions could be found through our previous optimized enhanced FST1-FLAIR. Healthy control group enrollment standard:At the same period, matched healthy subjects were recruited according to the sex, age and years of education of patients with intracranial tuberculosis.All of them were right-handed with an age of 16-70 years and education level of more than 6 years. Healthy people who were negative by tuberculosis pure protein derivative (PPD) skin test and had normal chest images.
Exclusion criteria
Exclusion criteria: Exclusion criteria for all subjects: 1. Dementias are caused by Alzheimer's disease, vascular dementia, Lewy body dementia and other causes. 2. Patients with cognitive impairment caused by endocrine and metabolic diseases, severe depression and other causes. 3. Cerebrovascular diseases, brain trauma, epilepsy and other nervous system diseases and mental system diseases. 4. Alcoholism or the use of glucocorticoids and drugs that affect brain function. 5. Patients with organic diseases such as heart, liver, kidney and known tumors. 6. Diabetes. 7. Pregnant and lactating women and women of childbearing age with long-term oral contraceptives. 8. There are stress conditions such as non-tuberculosis infection and operation in recent one month. 9. After metal material implantation, MRI examination was contraindicated.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity;Area Under the Curve; | — |
Countries
China
Contacts
Public ContactHou Dailun
Beijing Chest Hospital,Capital Medical University
Outcome results
None listed