actinic keratosis
Conditions
Interventions
ALA+PDD group:application of 20% ALA solution, and subsequent exposure to red light (635nm wavelength) with an energy density of 100-120J/cm2 for 30 minutes
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age between 50 and 75 years (inclusive), no restriction on gender. 2. Histopathologically confirmed cases of actinic keratosis (AK) on the head and face. 3. No cardiovascular or cerebrovascular disease, no liver or kidney dysfunction, and no neurological or sensory disorders. 4. Participants who agree to join this clinical trial and voluntarily sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Received local or systemic treatment for AK within the past 6 months. 2. Has severe cognitive, communicative, or mental disorders. 3. Allergic to ALA, other topical photosensitizers, or cream dressings. 4. History of photosensitivity disorders. 5. Presence of active infections, immune dysfunction, coagulation disorders, or malignancies. 6. Participation in any other research study within the past 30 days. 7. Deemed unsuitable for participation in this clinical trial for any other reasons determined by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete remission rate of AK lesions 3 months after the last therapy; | — |
Secondary
| Measure | Time frame |
|---|---|
| The recurrence rate of skin lesions at 6 months after the last treatment;The recurrence rate of skin lesions at 12 months after the last treatment;Partial remission rate of skin lesions in the third month after the last treatment; | — |
Countries
China
Contacts
Public ContactXian Jiang
West China Hospital, Sichuan University
Outcome results
None listed