Depression
Conditions
Interventions
depression with anhedonia:None
depression without anhedonia :None
Healthy controls :None
Sponsors
Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Patient group: 1. Age: 18-45 years; 2. Ethnicity: Han Chinese; 3. Right-handedness; 4. First-episode patients; 5. Education: At least primary school graduate Normal social functioning prior to illness: 6. Diagnostic criteria: Meets the criteria for major depressive disorder as outlined in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); 7. Medication history: No prior use of antipsychotics, antidepressants, benzodiazepines, or other central nervous system-affecting drugs; or antidepressant therapy limited to less than 2 weeks with monotherapy; 8. Voluntary participation in the study, with signed informed consent. For the anhedonia subtype of depression: Must meet the DSM-5 criteria for "loss of interest or pleasure"; Snaith-Hamilton Pleasure Scale (SHAPS) score > 5. Control group: 1. Age: 18-45 years; 2. Ethnicity: Han Chinese;3. Right-handedness; 4. Education: At least primary school graduate; 5. Normal social functioning; 6. Voluntary participation in the study, with signed informed consent.
Exclusion criteria
Exclusion criteria: Patient group: 1. Individuals with organic brain diseases, neurological disorders, or severe endocrine or metabolic diseases; 2. History of traumatic brain injury with a history of coma; 3. Previous diagnosis of other mental disorders as outlined in the DSM-5; 4. Non-compliance during assessments or inability to complete assessments effectively; 5. Presence of fixed metal dentures, cardiac pacemakers, or implanted metal prostheses. Control group: 1. History of mental illnesses diagnosed according to the DSM-5; 2. History of traumatic brain injury with a history of coma; 3. Positive family history of mental illness spanning two generations; 4. History of medication treatment involving antipsychotics, antidepressants, or similar; 5. Presence of fixed metal dentures, cardiac pacemakers, or implanted metal prostheses.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SHAPS scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| HAMD scores; | — |
Countries
China
Contacts
Public ContactSugai Liang
Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine
Outcome results
None listed