Subclinical hypothyroidism in the elderly
Conditions
Interventions
Control group:Only regular follow-up visits were received
LT4 group:Receive levothyroxine supplementation therapy, which will be adjusted to the normal range based on thyroid stimulating hormone (TSH) levels.
Sponsors
Suqian Hospital of Nanjing Drum Tower Hospital Group
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age >=65 years old. 2. Diagnosis is consistent with SCH. Diagnosis of SCH is based on at least 2 measurements of TSH (more than 3 months apart) above the upper limit of the TSH reference range and FT4 within the normal range. 3. Sign the informed consent form
Exclusion criteria
Exclusion criteria: 1. The subject has a history of use of levothyroxine, antithyroid drugs, amiodarone or lithium preparations in the past 3 months. 2. Thyroid surgery or radioactive iodine contact in the past 12 months. 3. Heart failure. New York Heart Association (NYHA) Class IV. 4. Cognitive dysfunction. 5. Hospitalization due to major illness or elective surgery in the past 3 months. 6. History of acute coronary syndrome, including myocardial infarction or unstable angina pectoris, in the past 3 months. 7. Untreated adrenal insufficiency or adrenal dysfunction. 8. Patients with acute infection, severe liver and kidney insufficiency, and tumors. 9. Subjects participating in ongoing randomized controlled trials of therapeutic interventions (including clinical trials of investigational drugs).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Carotid intima-media thickness;Mean of maximum plaque change at the last follow-up; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fatal and non-fatal cardiovascular events (acute myocardial infarction; Stroke; amputation of peripheral vascular disease; Atherosclerotic vascular disease, including acute coronary syndrome and heart failure hospitalizations.;Difference in left ventricular ejection fraction at 12 months from baseline;Performed at 1 year versus baseline Differences in cognitive function;Difference in blood pressure (systolic and diastolic) at 12 months from baseline;Differences in lipid profiles (total cholesterol, LDL cholesterol) between 12 months and baseline.;Bone mineral density differed at baseline and at the last follow-up visit at 12 months.; | — |
Countries
China
Contacts
Public ContactSun Yu
Suqian Hospital of Nanjing Drum Tower Hospital Group
Outcome results
None listed