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The association between repeated cryopreservation with the clinical pregnancy and perinatal outcomes in embryo transfer cycles of IVF/ICSI: a cohort study.

The association between repeated cryopreservation with the clinical pregnancy and perinatal outcomes in embryo transfer cycles of IVF/ICSI: a cohort study.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400092631
Enrollment
Unknown
Registered
2024-11-20
Start date
2024-11-20
Completion date
Unknown
Last updated
2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

repeated frozen-thawed embryo transfer

Interventions

Once-cryopreservation embryo transfer cycle group (cryopreservation group, single frozen-thawed times before transferred):None
Repeated cryopreservation embryo transfer cycle group (re-cryopreservation group, double frozen-thawed times before transferred):None

Sponsors

PEKING UNIVERSITY SHENZHEN HOSPITAL
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1.All FET cycles without cancelation after embryo warmed from the period between January 1, 2018 and December 31, 2022, in our reproductive medicine center were assessed.

Exclusion criteria

Exclusion criteria: 1. female age >45 years, (2) triple-or-more-cryopreserved embryo transfer cycles, (3) preimplantation genetic testing (PGT) cycles, (4)couples with chromosomal abnormalities, (5) patients with IVF/ICSI performed before in other hospitals, (6) uterine abnormalities (including bicornuate uterus, unicornuate uterus, etc.), (7) error of patient ART number or missing final IVF/ICSI outcomes, (8) the transfer cycles of twice-cryopreserved embryo mixed with fresh embryo or once-cryopreserved embryo or slow-freezing embryo.

Design outcomes

Primary

MeasureTime frame
Clinical pregnancy rate;

Secondary

MeasureTime frame
Embryo survival rate, embryo implantation rate, live birth rate, miscarriage rate, low birth weight rate, and preterm delivery rate;Maternal complications of gestational hypertension disease rate, congenital anomalies rate, stillbirth rate;

Countries

China

Contacts

Public ContactHuang Zengshu

PEKING UNIVERSITY SHENZHEN HOSPITAL

zshuang13@163.com+86 755 8392 3333

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026