None
Conditions
Interventions
Remimazolam:Induction and maintenance of general anesthesia using remifentanil sedation
propofol:Induction and maintenance of general anesthesia using propofol sedation
Sponsors
The First People´Hospital of Linping Disrrict,Hangzhou
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) Volunteers who are willing to cooperate with this study and have signed an informed consent form; 2) Patients with a CFS fatigue score of =4 on the day before surgery, selected according to the CFS fatigue scale; 3) Aged 65-85; 4) American Society of Anesthesiologists (ASA) grade II-III; 5) New York Heart Association (NYHA) cardiac function grade I-II; 6) BMI of 15-30 kg/m².
Exclusion criteria
Exclusion criteria: 1) Individuals who are resistant or allergic to benzodiazepines or other anesthetics; 2) Individuals with severe impairments in cardiopulmonary, liver, and renal functions; 3) Individuals who have been taking large amounts of sedatives, antidepressants, or analgesics for a long time; 4) Myasthenia gravis patients; 5) Individuals with severe mental or neurological disorders or craniocerebral trauma; 6) Individuals with a history of abnormal fat metabolism or allergic disorders; 7)History of alcohol abuse or grug dependence; 8) Individuals with communication difficulties or other reasons that make it difficult for them to cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| quality of Recovery -15 scale scores;inflammatory indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| MAP;HR;SPO2;Consciousness reaction time;Tracheal extubation time;Recovery room stay time;Drug use situation;Visual Pain Rating;Addition of annalgesics;Liver and kidney function indicators; | — |
Countries
China
Contacts
Public ContactCheng Mingxia
The First People´Hospital of Linping Disrrict,Hangzhou
Outcome results
None listed