Early Childhood Caries
Conditions
Interventions
Probiotic Group: Probiotics
Placebo Group:Placebo without Probiotics
Sponsors
Wuxi Children's Hospital
Eligibility
Sex/Gender
All
Age
3 Years to 6 Years
Inclusion criteria
Inclusion criteria: The experimental process adheres to the relevant rules, with children aged 3-6 years old; 1. All primary teeth have erupted; 2. No antibiotics or other antimicrobial drugs that could alter the oral flora have been used in the last month, nor have products containing probiotics; 3. No fluoride toothpaste has been used or fluoride treatments received in the last month; 4. Apart from dental caries, there are no other oral diseases or systemic diseases; 5. The number of decayed, missing, and filled teeth (DMFT) in children with ECC is >=6. The lifestyle remains unchanged and the children are in good health during the study period.
Exclusion criteria
Exclusion criteria: 1. Unable to attend follow-up visits within the specified time or explicitly express the intention to withdraw from the experiment, 2. The use of antibiotics during the intervention and washout period due to necessity, or the consumption of yogurt containing probiotics. Before recruiting volunteers, the doctors will explain the study content in detail to the guardians of the volunteers, obtain their consent, and have the guardians sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| oral microbiome changes;Streptococcus mutans levels;Candida albicans levels; | — |
Countries
China
Contacts
Public ContactXu Xianyin
Wuxi Children's Hospital
Outcome results
None listed