None
Conditions
Interventions
experimental group:Adjust the PEEP level
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients undergoing invasive mechanical ventilation; 2.those who agree to participate in this trial; 3.Patients aged >= 18 years old;
Exclusion criteria
Exclusion criteria: 1.Patients with pneumothorax, bullae, mediastinal emphysema, or pulmonary contusion; 2.Baseline oxygenation index 8 cmH2O, or Baseline Plate airway pressure (Pplat) > 30 cmH2O; 3.Pulmonary artery pressure > 50 mmHg; 4.Cardiac function >= Class III (Killip classification); 5.Hemodynamic instability, Mean Arterial Pressure (MAP) < 50 mmHg; 6.Congenital heart disease, such as atrial septal defect, ventricular septal defect, etc. 7.Concurrent diseases that may cause intracranial hypertension, such as craniocerebral injury, cerebrovascular disease, intracranial tumors, etc. 8.Poor echocardiographic imaging.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Right ventricular pulmonary artery coupling; | — |
Secondary
| Measure | Time frame |
|---|---|
| Stroke volume, SV;Pulmonary artery systolic pressure, PASP;End-systolic volume, ESV;Tricuspid regurgitation square, TRS;Fractional area change, FAC; | — |
Countries
China
Contacts
Public ContactHuang Lei
Peking University Shenzhen Hospital
Outcome results
None listed