Depression
Conditions
Interventions
Placebo group:Placebo
Sponsors
Jingzhou mental health center
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) aged =60; (2) meeting the diagnostic criteria for depression in the International Classification of Diseases, 10th Revision (ICD-10); (3) scoring =20 points in the first HAMD-24 assessment; (4) accompanied with gastrointestinal symptoms; (5) having signed the informed consent form by the legal guardian.
Exclusion criteria
Exclusion criteria: (1) A history of other clearly diagnosed mental disorders; (2) a history of manic episodes in the past or currently; (3) a history of serious physical illnesses in the past or currently; (4) having used antidepressants, mood stabilizers, steroid preparations, anti-inflammatory drugs, antibiotics, or immunomodulatory agents within the past month; (5) having undergone electroconvulsive therapy within the past month; (6) having used lactic acid bacteria products for =7 days within the past month; (7) having a history of alcohol or psychoactive substance abuse within the past three months; (8) patients with organic gastrointestinal disorders, such as peptic ulcer; (9) patients with gastrointestinal dysfunction caused by medication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale;Gastrointestinal Symptoms Rating Scale;Inflammatory factors; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale;Mini-Mental State Examination (MMSE) scale;Pittsburgh Sleep Quality Index (PSQI) scale;Treatment Emergent Symptom Scale ;Biochemical indicators; | — |
Countries
China
Contacts
Public ContactYuanyuan Fan
Jingzhou Mental Health Center
Outcome results
None listed