Hypertensive emergency
Conditions
Interventions
Enalaprilat group:None
Sponsors
Sun Yat sen Memorial Hospital of Sun Yat sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age range: 18-75 years old, male or female not limited; 2.Hypertensive emergency and hypertensive subacute patients requiring rapid control of blood pressure through intravenous medication;? Patients with clinic systolic blood pressure (SBP) = 180mmHg and/or clinic diastolic blood pressure (DBP) = 120mmHg, with or without target organ damage; ? Some patients have a history of elevated blood pressure that has caused corresponding target organ damage, have not received systematic antihypertensive/organ protection treatment, or have insufficient antihypertensive treatment. Although their blood pressure did not significantly increase at the time of diagnosis, the examination clearly indicates that they have developed acute pulmonary edema, aortic dissection, myocardial infarction, or acute stroke.
Exclusion criteria
Exclusion criteria: 1.Individuals who are allergic to angiotensin-converting enzyme inhibitors or have angioneurotic edema; 2.Estimated glomerular filtration rate (eGFR)<30 mL/min/1.73m2; 3.The research team has determined any clinical conditions that may limit compliance with the research process; 4.Participants have participated in another clinical trial within the past 30 days; 5.The subject has already used or is about to use urinary tract infections during the treatment process; 6.Intravenous thrombolysis therapy (such as intravenous injection of rtPA); 7.Pregnant or planning to conceive or breastfeed women; 8.Known to account for over 70% of patients with bilateral renal artery stenosis and isolated kidney; 9.Without obtaining informed consent from the subjects;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change curve of blood pressure after medication; The magnitude and compliance rate of blood pressure drop 6 hours after medication; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in heart rate from baseline at 1h, 6h, and 12h after medication;Changes in NT proBNP after medication compared to baseline;Changes in SpO2 compared to baseline at 6h and 12h after medication;Changes in blood creatinine compared to baseline 12 hours after medication;Changes in electrolyte sodium, potassium, and chloride ions compared to baseline 12 hours after medication; | — |
Countries
China
Contacts
Public Contactjianglongyuan
Sun Yat sen Memorial Hospital of Sun Yat sen University
Outcome results
None listed