Irritable Bowel Syndrome
Conditions
Interventions
Control group:Restrict a similar amount of food as the other two groups, and the restriction difficulty is similar, but do not affect the intake of nutrients, fiber or fermentable oligosaccharides, di
Low FODMAP group:Limit intake of foods containing the following components: fructose, lactose, fructan and galactooligosaccharides, sugar alcohols.
Probiotics + Low FODMAP group:Based onthe limiting foods in the LFD group, foods rich in probiotics will be added
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Meet the RomeIV diagnostic criteria for diarrheal IBS; 2. 18-60 years old; 3. IBS Symptom Severity Scale (IBS-SSS) score =175.
Exclusion criteria
Exclusion criteria: 1. Conditions that may affect the gut microbiota (e.g., inflammatory bowel disease, celiac disease, diabetes); 2. Patients with abdominal pain and diarrhea due to organic diseases; 3. Patients with abdominal surgery; 4. Patients with complications of heart, brain, liver, kidney and other systems; 5. Patients with organic diseases and biochemical abnormalities, such as abnormalities with hyroid function, blood routine, tumor markers, stool routines, abdominal B-scan ultrasonography, endoscopy, and other related examinations. 6. The duration of abdominal discomfort symptoms < 2 days; 7. Patients with serious mental problems or take related drugs; 8. Drug abusers or alcoholics; 9. Patients with special dietary habits (such as vegetarians); 10. People suffering from eating disorders; 11. Use of antibiotics, probiotics, and other drugs that may affect the study, and pre-colonoscopy bowel preparation within 4 weeks prior to the study; 12. Participants in other clinical trials; 13. Patients undergoing therapeutic dietary interventions; 14. Pregnant or lactating women; 15. Patients unable to communicate normally or unable to use communication equipment expertly; 16. Don't want to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Irritable Bowel Syndrome Symptom Severity Scale, IBS-SSS; | — |
Secondary
| Measure | Time frame |
|---|---|
| IBS-QOL;Bristol stool form scale;Hospital Anxiety and Depression Scale, HADS;Patient Health Questionnaire, PHQ-12;hydrogen breath test;Metabolomics indicators;gut microbiota; | — |
Countries
China
Contacts
Public ContactLiu Wei
Peking University Third Hospital
Outcome results
None listed