Ulcerative colitis
Conditions
Interventions
The metformin group:Metformin hydrochloride enteric enema
Control Group:Saline enema
Sponsors
The First Affiliated Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1: Age 18-70 years old, gender is not limited 2: Subjects with confirmed ulcerative colitis(involving rectum and/or sigmoid) were evaluated by endoscopy, histology, and imaging 3: Subjects receiving medication 4: Patients voluntarily sign informed consent forms
Exclusion criteria
Exclusion criteria: 1: Patients with severe ulcerative colitis 2: Patients treated with systemic or rectal steroids 3: Patients known to be allergic to any investigational drug 4: Patients with liver and kidney dysfunction 5: Pregnant and lactating patients 6: Patients with a history of colorectal cancer 7: Patients with a history of total or partial colectomy 8: Current or former metformin therapy for female subjects with polycystic ovary syndrome 9: Diabetic subjects with a history of lactic acidosis, and subjects with disease status associated with hypoxemia, including cardiopulmonary insufficiency 10: Patients with positive fecal cultures for intestinal pathogens and positive tests for fecal eggs and parasites
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endoscopic score;Histological score;Improved Mayo Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| ESR;CRP;Fecal calvetin;Fecal lactoferrin; | — |
Countries
China
Contacts
Public ContactZhe Shen
The First Affiliated Hospital, College of Medicine, Zhejiang University
Outcome results
None listed