depression
Conditions
Interventions
Experimental group1:Functional connectivity localization group
Experimental group2:Classical coordinate localization group
Healthy control group:None
Sponsors
The Affiliated Hospital of Hangzhou Normal University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Patients diagnosed with depression who meet the DSM-5 criteria for depression diagnosis; (2) HAMD>17 points (Melzer et al., 2012); The Chinese version of the Mood Disorder Questionnaire (MDQ) scores less than 7 points; (3) Using the Brief International Neuropsychiatric Interview 7.0.0 (M.I.N.I. 7.0.0) to confirm that the subject is currently experiencing a depressive episode; (4) Gender is not limited, age range is 18-65 years old; (5) Subjects who can understand and are willing to strictly follow the clinical trial protocol to complete this trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Individuals with contraindications to magnetic resonance imaging and TMS. (2) Serious heart, liver, and kidney diseases, no history of thyroid, tumor, hematological disorders, rheumatism, malnutrition, or neurological disorders. (3) Schizophrenia, bipolar disorder, history of tobacco, alcohol, and other psychoactive substance abuse. (4) The patient is a pregnant or lactating woman or a planned pregnancy. (5) Not taking immune modulators and hormone preparations for at least six months, and not taking antipyretic and analgesic drugs for two weeks. (6) Patients who have received ECT or TMS treatment within two months. (7) Researchers believe that it is not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale;Self-rating depression scale;Anxiety self-rating scale;Insomnia Severity Index Scale;Baker Suicidal Ideation Scale;Visual analogue scale;Mood Disorder Questionnaire;Snaith-Hamilton Pleasure Scale;Digit-symbol substitution test;digital span test; | — |
Countries
China
Contacts
Public ContactZhao Na
Hangzhou Normal University
Outcome results
None listed