Gingival inflammation
Conditions
Interventions
Experimental group:The test group used the toothpaste containing potassium glycyrrhizinate, and other ingredients included sorbitol, water, hydrated silica, sodium lauryl sulfate, essence, cellulose g
Control group:The control group used the toothpaste without potassium glycyrrhizinate, and the other ingredients included sorbitol, water, hydrated silica, sodium lauryl sulfate, essence, cellulose gu
Sponsors
Third Affiliated Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Good overall health condition and no systemic diseases; 2) Both males and females are welcome, aged between 18 and 60 years old; 3) There are more than 20 natural teeth, no extensive restorations in the neck of the teeth, no untreated cavities in the teeth, no severe gum recession, and no severe gum recession Periodontal disease; 4) Improved Quigley Hein plaque index>= 1.0; 5) Loe Silness gingivitis index >= 1.0, bleeding index >= 1.0 or (BOP% >= 50%); 6) No history of allergies to the ingredients of the experimental toothpaste; 7) Sign informed consent form, comply with trial rules and requirements, and complete a 4-month clinical trial.
Exclusion criteria
Exclusion criteria: 1) Currently participating in clinical trials in other dental specialties. 2) Currently pregnant, breastfeeding, or having a pregnancy plan within the trial period. 3) Teeth have extensive restorations, suspected pulpitis, dental caries, enamel cracks, and removable partial dentures. 4) Late stage of periodontal disease or received periodontal treatment (including periodontal surgery) within the past year. 5) Take anti-inflammatory, antibacterial, or statin drugs during the trial period. 6) Those who wear full mouth or removable partial dentures or orthodontic appliances. 7) More than 6 subjects with severe staining on the tooth surface during testing. 8) Patients with diabetes. 9) Allergies to any ingredients of the research product. 10) Take dietary supplements (such as multiple vitamins, antioxidants, fish oil, etc.). 11) Use antibiotics within two weeks before the start of the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gingival Index (GI);Bleeding Index (BI);Plaque Index (PI); | — |
Countries
China
Contacts
Public ContactXiaomian Wu
Third Affiliated Hospital of Southern Medical University
Outcome results
None listed