heart failure with reduced ejection fraction and heart failure with mildly reduced ejection fraction
Conditions
Interventions
Observation group:None
Sponsors
Beijing Tsinghua Changgung Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age>=18 years. People with chronic heart failure who meet the diagnostic criteria for heart failure in the 2024 Chinese Guidelines for the Diagnosis and Treatment of Heart Failure, with mildly decreased ejection fraction and decreased ejection fraction and improved ejection fraction. The following conditions are met: 1. Medical history: coronary atherosclerotic heart disease, hypertension, high-risk factors for heart failure, use of diuretics, orthopnea/paroxysmal dyspnea at night 2. Signs: pulmonary rales, edema of both lower extremities, heart murmur, jugular venous distention, lateral or diffuse apical pulsation 3. Chest X-ray showed pulmonary congestion/edema, heart enlargement, and abnormal electrocardiogram 4. NT-proBNP>=125ng/L or BNP>=35ng/L, or strong suspicion of heart failure or NT-proBNP/BNP is not available 5. Echocardiography shows LVEF <50% NYHA Grading II-III
Exclusion criteria
Exclusion criteria: People who have a clear diagnosis of atrial fibrillation or atrial flutter in the past Patients with atrial pacing dependence Patients with acute heart failure and acute exacerbations of chronic heart failure History of severe liver and kidney disease (eGFR<30 mL/min/1.73m^2), severe lung disease, malignant tumor and psychiatric disease; Pregnant women, women of childbearing potential who plan to become pregnant during the study or are unable to achieve effective contraception during the study Life expectancy < 12 months due to the disease; Not signed informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Atrial fibrillation;Atrial flutter;Subclinical atrial fibrillation; | — |
Secondary
| Measure | Time frame |
|---|---|
| All-cause mortality;Major cardiovascular events;Kansas City Cardiomyopathy Questionnaire (KCCQ-12) scores; | — |
Countries
China
Contacts
Public ContactRong He
Beijing Tsinghua Changgung Hospital
Outcome results
None listed