intubated
Conditions
Interventions
Test group:Oxycodone Hydrochloride Injection continuous infusion therapy was administered
Control group:Remifentanil Injection continuous infusion was administered
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) 18 = 24 hours;
Exclusion criteria
Exclusion criteria: 1) Patients requiring deep sedation (e.g., severe human-machine asynchrony in mechanically ventilated patients, respiratory distress due to severe respiratory failure, use of neuro-muscular blocking agents, status epilepticus, postoperative surgery requiring strict immobilization, hypothermia treatment, etc.); 2) Chronic kidney disease, severe liver dysfunction (Child-Pugh grade C); 3) severe shock requiring norepinephrine =0.5 µg/kg/min; 4) American Society of Anesthesiologists (ASA) classification class 5 patients (near death); 5) Nerve damage or organic pathological changes in the brain; 6) Requires a specified sedative or anesthetic other than the study drug during treatment; 7) patients with chronic pain, often using strong opioids, such as morphine; 8) history of alcohol or drug abuse; 9) Participation in other opioid investigations within 30 days; 10) Pregnant or lactating women; 11) Patients with allergies and contraindications to the study drug; 12) Patients judged by the investigator to be unsuitable for inclusion in the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of time with CPOT < 3 without rescue analgesia within 7 days of mechanical ventilation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Days without mechanical ventilation within 28 days;Change in gastrointestinal function within 7 days of dosing;Ventilator-associated pneumonia;AE;Successful extubation rate within 28 days;Los;Delirium; | — |
Countries
China
Contacts
Public ContactZhong Ming
Zhongshan Hospital, Fudan University
Outcome results
None listed