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A study on the pathophysiological changes of islet and underlying mechanism in the process of type 2 diabetes mellitus

A study on the pathophysiological changes of islet and underlying mechanism in the process of type 2 diabetes mellitus

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400092493
Enrollment
Unknown
Registered
2024-11-18
Start date
2024-11-18
Completion date
Unknown
Last updated
2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes

Interventions

Normal group:None
T2D group:None

Sponsors

Shanghai Changzheng Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Normal group: 1. BMI < 24 kg/m² and not diagnosed with diabetes or other pancreatic diseases; 2. Aged between 18 and 70 years old; 3. Informed consent of the individual or legal representative. Obesity group: 1. BMI = 24 kg/m² and not diagnosed with diabetes or other pancreatic diseases; 2.Aged between 18 and 70 years old; 3.Informed consent of the individual or legal representative. T2D group: 1. Diagnosed with T2DM and not accompanied by other pancreatic diseases; 2.Aged between 18 and 70 years old; 3. Informed consent of the individual or legal representative.

Exclusion criteria

Exclusion criteria: 1.Other types of diabetes (e.g., T1D); 2.Other diseases of pancreas (e.g., pancreatitis); 3. Systemic autoimmune diseases that may damage pancreatic tissue (e.g., systemic lupus erythematosus); 4.Severe systemic inflammation that may damage pancreatic tissue (e.g., systemic inflammatory response syndrome); 5.Advanced tumor invasion of pancreatic tissue; 6. Aged under 18 or above 70 years old.

Design outcomes

Primary

MeasureTime frame
Body mass index;

Secondary

MeasureTime frame
Complete blood count and urinalysis;Liver and renal function biomarkers;Coagulation function index;Transabdominal ultrasound;Random blood glucose;Electrolyte;Myocardial markers;Inflammatory factor;

Countries

China

Contacts

Public ContactHuating Li

Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

huarting99@sjtu.edu.cn+86 139 1650 2465

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026