hypertension
Conditions
Interventions
Bilateral adrenal artery ablation + spironolactone group:Bilateral adrenal artery ablation + spironolactone
Sponsors
Army Medical Center of PLA
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Hypertensive patients aged 18-70 years; 2. The initial screening showed an aldosterone/renin ratio (ARR)>3.7, baseline aldosterone level>10ng/dl, aldosterone level>6ng/dl after saline stress test, or a 30% decrease in aldosterone after captopril inhibition test, which is consistent with the diagnosis of primary aldosterone; 3. Patients who have not received treatment or are currently receiving antihypertensive medication (medication treatment for blood pressure<180/110mmHg); 4.Adrenal vein blood sampling suggested idiopathic aldosteronism; 5.Voluntarily participate in the experiment and sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1. Room blood pressure>180/110mmHg; 2. Severe liver dysfunction (Child Pugh rating of C) or renal dysfunction (eGFR<30mL/min/1.73m ^ 2); Acute coronary syndrome, myocardial infarction, percutaneous coronary intervention, and cerebrovascular accident occurred within 3.6 months; NYHA grade II-IV heart failure; 4. Blood potassium levels are below 2.5mmol/L or above 5.5mmol/L; 5. Pregnancy or planning to conceive within one year; 6. Suffering from neurological and mental illnesses; 7. Combination of malignant tumors; 8. The researcher believes that any other reasons that may affect the efficacy and/or safety evaluation of this study and are not suitable for participation in this clinical trial (including but not limited to the researcher's judgment that the subjects have poor compliance, or reside far away and cannot be followed up on schedule);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24 hours ambulatory blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| office blood pressure;Plasma aldosterone;24-hour urinary aldosterone;plasma rennin;Serum potassium; | — |
Countries
China
Contacts
Public ContactZhu Zhiming
Army Medical Center of PLA
Outcome results
None listed