hypertension
Conditions
Interventions
Control group:convention exercise training
Sponsors
Yancheng the third people's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age: >= 60 years old, both male and female are eligible. 2. Diagnosis of hypertension: Diagnosed with primary hypertension (systolic blood pressure >= 140 mmHg or diastolic blood pressure >= 90 mmHg, or long-term use of antihypertensive drugs to control blood pressure). Stable blood pressure control (no significant fluctuations or acute exacerbations in the past three months). 3. Functional status: able to walk independently, live independently, have a certain endurance, and can engage in mild to moderate intensity exercise. 4. Cognitive status: No severe cognitive impairment (such as Alzheimer's disease or other severe cognitive disorders), able to understand and follow experimental instructions (Mini Mental State Examination score = 24). 5. Training compliance: Interested in participating in BFR training and willing to follow the experimental requirements, able to participate in at least 3 training sessions per week for 12 weeks. 6.Informed consent: Understand the purpose and process of this study, sign the informed consent form, and voluntarily participate in this study.
Exclusion criteria
Exclusion criteria: Exclusion criteria related to cardiovascular disease: 1.Serious cardiovascular events (such as myocardial infarction, stroke, unstable angina, severe arrhythmia) have occurred in the past 6 months. 2.Diagnosed with chronic heart failure (New York College of Cardiology functional class III-IV). 3.There are peripheral arterial diseases (such as occlusive arteriosclerosis) or thrombotic diseases (such as deep vein thrombosis, pulmonary embolism, etc.) to avoid exacerbating the condition during blood flow restriction. 4.Diagnosed as severe valve disease (such as severe aortic stenosis, severe mitral regurgitation). 5.Implanted pacemakers or cardiac resynchronization therapy (CRT) devices may cause changes in heart rate and conduction due to BFR. Exclusion criteria related to blood vessels and blood system: 1.The presence of bleeding disorders or coagulation dysfunction (such as hemophilia, severe thrombocytopenia), or long-term use of anticoagulant drugs (such as warfarin, rivaroxaban, etc.). 2.There are clear vascular structural abnormalities (such as aortic aneurysms, vascular aneurysms) or arteriovenous fistulas to avoid damage to blood vessels during blood flow restriction. Patients with severe hypertension: 1.Hypertension that cannot be controlled even with antihypertensive medication for individuals with resting systolic blood pressure >= 180 mmHg or diastolic blood pressure >= 110 mmHg. 2.The patient cannot tolerate mild exercise or severe fluctuations in blood pressure during exercise (systolic blood pressure increase>40 mmHg or diastolic blood pressure increase>20 mmHg after exercise). Serious cognitive or mental health issues: 1.Having a mental illness (such as severe depression, schizophrenia) that has not been effectively controlled, or being unable to understand or follow experimental instructions due to cognitive impairment. 2.Has serious behavioral problems or is unable to cooperate with the research process (such as severe emotional instability, aggressive behavior).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulse wave velocity,PWV;Blood flow mediated dilation, FMD;Cognitive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;Baseline MRI(Magnetic Resonance Imaging); | — |
Countries
China
Contacts
Public ContactWang Rui
Yancheng the third people's Hospital
Outcome results
None listed